Little Group Publications

Little Group Publications

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Recent Publications

• Patrick Enders, Michal Májek, Chiu Marco Lam, R. Daniel Little, and Robert Francke, How to Harness Electrochemical Mediators for Photocatalysis – A Systematic Approach Using the Phenanthro[9,10-d]imidazole Framework as a Test Case, ChemCatChem 2022, e202200830,

• Jee, D. W.; Myung, J.; Little, R. D.; Han, S.; Lee, H-Y. Alkylidene Carbene from Silyl Vinyl Iodide Provides Mechanistic Insights on Trimethylenemethane Diyl-Mediated Tandem Cyclizations, Org. Lett. 2022, 24, 4399–4403,

Eric C. R. McKenzie, Seyyedamirhossein Hosseini, Ana G. Couto Petro, Kelly K. Rudman, Benjamin H. R. Gerroll, Mohammad S. Mubarak, Lane A. Baker, and R. Daniel Little, Versatile Tools for Understanding Electrosynthetic Mechanisms, Chem. Rev. 2022, 122(3), 3292-3335. DOI: 10.1021/acs.chemrev.1c00471

• Francke, R.; Prudlik, A.; Little, R. D., In Science of Synthesis: Electrochemistry in Organic Synthesis, Ackermann, L., Ed.; Thieme: Stuttgart, (2021); Vol. 1, p 293-324 (DOI: 10.1055/sos-SD-236-00029) Science of Synthesis: Electrochemistry in Organic Synthesis, (2021) 1, 293.

• Little, R.D. JOC Perspective entitled: “A Perspective on Organic Electrochemistry, J. Org. Chem. 2020, Publication Date: August 28, 2020

• Jiang, Yang-ye; Dou, Gui-yuan; Zhang, Luo-sha; Xu, K.; Little, R. D.; Zeng, Cheng-chu, Electrochemical cross-coupling of C(sp2)-H with aryldiazonium salts via a paired electrolysis: an alternative to visible light photoredox-based approach, Adv. Synth. Cat. 2019, 361, DOI: 10.1002/adsc.201901011

• Francke, R.; Little, R. D. “Organic Electrosynthesis”, ChemElectroChem, 2019, 6 (17), front cover (DOI: 10.1002/celc.201900432)

• Francke, R.; Little, R.D.; Shinsuke I., co-editors, ChemElectroChem 2019, 6, 4065– 4066 editorial commentary [DOI: 10.1002/celc.201901175]

• Francke, R.; Little, R. D. Electrons and Holes as Catalysts in Organic Electrosynthesis, ChemElectroChem, 2019, 6, 4373-4382 []

Francke, R.; Gonzalez, L. A.; Little, R. D.; Moeller, K. D. Electrons, Electrodes, and the Transformation of Organic Molecules, Volume 10 of Surface and Interface Science, Wiley-VCH Verlag GmbH & Co. KGaA, Berlin, 2019

• Little, R. D.; Moeller, K. D. Introduction: Electrochemistry: Technology, Synthesis, Energy, and Materials Chem. Rev. 2018, 118, 4483-4484 (editorial commentary)

• “Electrochemistry: Technology, Synthesis, Energy, and Materials” Co-editor with K. D. Moeller of special issue of Chemical Reviews, Chem. Rev. 2018, 118 (9), 4483-4886

• Johnson, B. M.; Francke, R.; Little, R.D.; Berben, L. A.  High turnover in electro-oxidation of alcohols and ethers with a glassy carbon-supported phenanthroimidazole mediator, Chem. Sci. 2017, 8, 6493-6498 (DOI: 10.1039/C7SC02482G)

• Jiang, Y.-y.; Liang, S.; Hu, L-M.; Little, R. D.; Zeng, C-C. Electrochemical oxidative amination of sodium sulfinates: synthesis of sulfonamides mediated by NH4I as a redox catalyst, J. Org. Chem. 2016, DOI: 10.1021/acs.joc.6b00615

  • Kang, L-S.; Luo, M-H.; Lam, C.M.; Hu, L.; Little, R. Daniel; Zeng, C-C. Electrochemical C-H functionalization and subsequent C-S and C-N bond formation: Paired electrosynthesis of 3-amino-2-thiocyanato-a,ß-unsaturated carbonyl derivatives mediated by bromide ion, Green Chemistry, 2016, DOI: 10.1039/C6GC00666C
  • Springer, S. D.; He, J.; Chui, M.; Little, R. D.; Foston, M.; Butler, A. Peroxidative Oxidation of Lignin and a Lignin Model Compound by a Manganese SALEN Derivative, ACS Sustainable Chemistry & Engineering, 2016, DOI: 10.1021/acssuschemeng.6b00245
  • Herold, S.; Waldvogel, S. R.; Little, R. D.; Yoo, S. J. Applicability of a Polymerized Ionic Liquid /Carbon Nanoparticle Composite Electrolyte to Reductive Cyclization and Dimerization Reactions, Electrochimica Acta, 2016, 196, 735-740
  • Zhang, K.-Y.; Lu, N.; Yoo, S.J.; Hu, L.-M.; Little, R.D.; Zeng, C.-C. Electrochemical analysis of the triarylimidazole-type organic redox catalysts: reversibility and homogeneous electron transfer kinetics for the oxidation of 4-methoxybenzyl alcohol, Electrochimica Acta, 2016, DOI: 10.1016/j.electacta.2016.02.132
  • Kang, L.-S.; Xiao, H.-L.; Zeng, C.-C.; Hu, L. M.; Little, R. D. Electrochemical Synthesis of Benzoxazoles Mediated by 2,3-Dichloro-5,6-dicyano-p-hydroquinone (DDH) as a Redox Catalyst, J. Electroanal. Chem. 2016, DOI: 10.1016/j.jelechem.2015.12.051
  • Liang, S.; Zeng, C-C.; Luo, X-G.; Ren, F-Z.; Tian, H-Y.; Sun, B-G.; Little, R.D. Electrochemically catalyzed amino-oxygenation of alkenes?a n-Bu4NI induced C-N followed by C-O bond formation cascade for the synthesis of indolines, Green Chemistry, 2016, 18, 2222-2230.  DOI: 10.1039/C5GC02626A
  • Li, L.; Jiang, Y.; Zeng, C-C; Hu, L-M.; Tian, H-Y.; Lam, C. M.; Little, R. D.  Aromatic C-H bond functionalization induced by electrochemically in situ generated tris(p-bromophenyl)aminium (TBPA) radical cation: cationic chain reactions of electron-rich aromatics with enamides, J. Org. Chem. 2015, 80(21), 11021-11030; DOI: 10.1021/acs.joc.5b02222
  • Chen, J.; Yan, W-Q.; Lam, M.; Zeng, C-C.; Hu, L-M.; Tian, H-Y.; Little, R.D. Electrocatalytic Aziridination of Alkenes Mediated by n-Bu4NI: A Radical Pathway Org. Lett. 2015,
  • Yoo, S. J.; Li, Long-Ji; Zeng, C-C.; Little, R. D. Polymeric Ionic Liquid and Carbon Black Composite as a Reusable Supporting Electrolyte: Modification of the Electrode Surface, Angewandte Chemie, Int. Ed. 2015, in the International Edition and in the German Edition.
  • R. K. Gbur, R. D. Little, Electrosynthesis of Bioactive Materials, in Organic Electrochemistry (5th edition), B. Speiser, O. Hammerich (Eds.), 2015, Taylor & Francis.
  • J. H. P. Utley, R. D. Little, M. F. Nielsen, Reductive Coupling, in Organic Electrochemistry (5th edition), B. Speiser, O. Hammerich (Eds.), 2015, Taylor & Francis.
  • Lu, N-N.; Zhang, N-T.; Zeng, C-C.; Hu, L-M.; Yoo, S.J.; Little, R. D. Electrochemically induced ring-opening/Friedel-Crafts arylation of chalcone epoxides catalyzed by a triarylimidazole redox mediator, J. Org. Chem. 2014, 79,
  • Gao, W-J.; Li, W-C.; Zeng, C-C.; Tian, H-Y.; Hu, L-M.; Little, R. D. Efficient Electrochemical Oxidative Aminations of Benzoxazoles using Alkylammonium Halides as Redox Catalysts J. Org. Chem. 2014, 79 (20), 9613–9618,
  • N. Lu, S. Joon Yoo, Long-Jie Li, C.C. Zeng, R. D. Little, A comparative study of organic electron transfer redox mediators: electron transfer kinetics for triarylimidazole and triarylamine mediators in the oxidation of 4-methoxybenzyl alcohol Electrochim. Acta, 2014, 142, 254-260
  • Xiao, H-L.; Zeng, C-C.; Tian, H-Y.; Hu, L-M.; Little, R.D, Electrochemical synthesis of 3,5-disubstituted isoxazoles, J. Electroanal. Chem. 2014, 727, 120-124
  • R. Francke, R. D. Little, Redox Catalysis in Organic Electrosynthesis: Basic Principles and Recent Developments, Chem. Soc. Rev. 2014, 43, 2492–2521 (front cover). [DOI: 10.1039/C3CS60464K]
  • R. Francke, R. D. Little, Optimizing Electron Transfer Mediators Based on Arylimidazoles by Ring Fusion: Synthesis, Electrochemistry and Computational Analysis of 2-Aryl-1-methyl-phenanthro[9,10-d]imidazoles, J. Am. Chem. Soc. 2014, 136, 427–435.[DOI: 10.1021/ja410865z]
  • C. Li, C.-C. Zeng, L.-M. Hu, F.-L. Yang, R. D. Little, Electrochemically induced C-H functionalization using bromide ion/TEMPO dual redox catalysts in a two-phase electrolyte system, Electrochim. Acta 2013, 114, 560-566. [DOI: 10.1016/j.electacta.2013.10.093]
  • W.-C. Li, .; C.-C. Zeng, L.-M. Hu, H.-Y. Tian, R. D. Little, Efficient indirect electrochemical synthesis of 2-substituted benzoxazoles using NaI as a mediator Adv. Synth. Catal. 2013, 355, 2884–2890. [DOI: 10.1002/adsc.201300502]
  • D. R. Day, S. Jabaiah, R. S. Jacobs, R. D. Little, Cyclodextrin Formulation of the Marine Natural Product Pseudopterosin A Uncovers Optimal Pharmacodynamics in Proliferation Studies of Human Umbilical Vein Endothelial Cells, Mar. Drugs, 2013, 11, 3258-3271. [DOI: 10.3390/md11093258]
  • N.-T. Zhang, C.-C. Zeng, C. M. Lam, R. K. Gbur, R. D. Little, Triarylimidazole Redox Catalysts: Electrochemical Analysis and Empirical Correlations, J. Org. Chem. 2013, 78, 2104–2110. [DOI: 10.1021/jo302309m ]
  • H.-L. Xiao, C.-W. Yang, N.-T. Zhang, C.-C. Zeng, L.-M. Hu, H.-Y. Tian, R. D. Little, Electrochemical oxidation of aminophenols in the presence of benzenesulfinate, Tetrahedron 2012, 69, 658-663. [DOI: 10.1016/j.tet.2012.11.005 ]
  • R. D. Little, Anodic Substitutions, in Encyclopedia of Applied Electrochemistry, R. F. Savinell, K.-I. Ota and G. Kreysa, (Eds), 2012, Springer, New York.
  • C.-C. Zeng, N.-T. Zhang, C. M. Lam, R. D. Little, Novel triarylimidazole redox catalysts: synthesis, electrochemical properties and applicability to electrooxidative C-H activation, Org. Lett., 2012, 14, 1314-1317. [DOI: 10.1021/ol300195c ]
  • R. Gbur, ; R. D. Little, Unveiling the Role of Molecule-Assisted Homolysis: A Mechanistic Probe into the Chemistry of a Bicyclic Peroxide, J. Org. Chem. 2012, 77, 2134-2141. [DOI: 10.1021/jo300297u ]